Gentamycin
Trade name: Garamyein.
Class: - antibiotic, aminoglycoside.
Pregnancy: (Category C)
Indication:
v
It is the drug of choice
for hospital- acquired gram negative
sepsis including neonatal sepsis.
v
Serious staphylococcal
infections.
Side effects
§
blood
pressure, alopecia
blood
pressure, alopecia
§CNS:
ototoxicity, tinnitus, dizziness, ringing in the ears, vertigo.
§
GI:
nausea, vomiting, anorexia, weight loss, increased salivation.
§
C.V.:
palpitation, hypotension or hypertension.
§
Hematologic:
Decrease number of blood cells.
§
GU:
nephrotoxicity
§
Local:
Pain and irritation at IM injection site.
Formulation:-
Vial 2 ml containing 20 mg.
Ampoule 2 ml containing 80 mg.
Dosage:-
v
I.M. (usual). I.V. adults 3
mg\kg q 8 hr up to 5 mg\kg daily.
Children 2-2.5 mg\kg q 8 hr.
Newborns 2.5 mg\ kg q 12 hr.
Ophthalmic solution 0.3%, 1-2 drops q 15-30 minutes.
Topical ointment 0.1%, 1-5 times daily to the affected
area.
Streptococcal or enterococcal endocarditis
in combination with other drugs, 80 mg twice daily.
N.B.:-
Should not be mixed
with other drugs for parenteral use.
Nursing implication:
§ When given IM, give it slowly and deep in the muscle.
§ Dilute
dose when given IV.
§ Monitor for kidney function tests, complete blood count when
used for more than 7 days. Consult with Dr. accordingly.
