Tranexamic Acid
Trade names: Cyklokapron, Hexacapron
Class: Antifibrinolytic drugs and haemostatic
Pregnancy:
(Category B) Action:
Tranexamic acid is an Antifibrinolytic that
competitively inhibits the activation of plasminogen to plasmin.
Uses:
This medication is used for short-term
control of bleeding in hemophiliacs, including dental extraction procedures.
Dose:
§ by mouth, local fibrinolysis, 15–25 mg/kg 2–3 times daily
Menorrhagia (initiated when menstruation
has started), 1 g 3 times daily for up
to 4 days; max. 4 g daily
§ Hereditary angioedema, 1–1.5 g 2–3 times daily
By
slow intravenous injection, local fibrinolysis, 0.5–1 g 3 times daily " 10 mg /kg "
Contraindications:
In patients with acquired defective color
vision, since this prohibits measuring one endpoint that should be followed as
a measure of toxicity. 
In patients with subarachnoid hemorrhage.
Anecdotal experience indicates
that cerebral edema and cerebral infarction
may be caused by CYKLOKAPRON in such patients.
In patients with active intravascular
clotting.
Side effects:
Nausea, vomiting, diarrhea might occur.
If these persist or worsen, notify your doctor promptly. Very unlikely but
report promptly: vision changes, dizziness.
Nursing
considerations:
§
For intravenous infusion,
CYKLOKAPRON Injection may be mixed with most solutions for infusion such as
electrolyte solutions, carbohydrate solutions, amino acid solutions and Dextran
solutions.
§
The mixture should be
prepared the same day the solution is to be used.
§
CYKLOKAPRON Injection
should NOT be mixed with blood.
§ The
drug is a synthetic amino acid, and should NOT be mixed with solutions
containing penicillin.
