Streptokinase
Trade names:
streptase
Class: Thrombolytic agent.
Pregnancy:
(Category C) Action:
Acts with plasminogen to produce an activator complex which enhance the
conversion of plasminogen to plasmin which breaks down fibrinogen fibrin clot
& other plasma proteins.
Uses:
Deep venous thrombosis (DVT)
Myocardial infarction (MI)
To clear occluded arteriovenous or IV canula .
Dose:
myocardial infarction, 1 500 000
units over 60 minutes
Deep-vein
thrombosis, pulmonary embolism, acute arterial thromboembolism, central retinal
venous or arterial thrombosis, by intravenous infusion, 250 000 units over 30
minutes, then 100 000 units every hour for up to 12–72 hours according to
condition with monitoring of clotting parameters Contraindications:
Hemorrhage.
Side effects:
Bleeding,
nausea, and 
headache.
Nursing
considerations:
Before using Streptase, Streptokinase, an
attempt should be made to clear the cannula by careful syringe technique, using
heparinized saline solution. If adequate flow is not re-established,
Streptokinase may be employed
Clamp off cannula limb(s) for 2 hours. Observe
the patient closely for possible adverse effects. After treatment, aspirate contents of infused
cannula limb(s), flush with saline, reconnect cannula.
