Cefazolin
Trade name: Ancef, Kefzol.
Class: Antibiotic "cephalosporines" FIRST GENERATION Pregnancy:
(Category B)
Action: Bind to bacterial cell wall membrane,
causing cell death.
Uses:
Treatment of:
• Skin and skin structure infections (including burn wounds) Pneumonia.
• Otitis media.
• Urinary tract infections.
• Bone and joint infections.
• Septicemia (including endocarditic) caused by susceptible
organisms.
• Perioperative prophylaxis. Dose
By intramuscular injection or intravenous
injection or infusion, 0.5–1 g every 6–12
hours; CHILD, 25–50 mg/kg daily (in divided doses), increased to 100 mg/kg
daily in severe infections
Contraindications:
• Hypersensitivity to cephalosporin or Penicillin, renal failure,
Pregnancy, Lactation.
Side effects:
• Nausea, vomiting, diarrhea, anorexia, abdominal pain,
flatulence, skin rashes super-infection, heartburn, sore mouth, bone marrow
depression: (Decrease WBC, decreased platelets, decreased Hct), Nephrotoxicity,
(pain, abscess at injection site, phlebitis and inflammation at IV site.
Nursing considerations:
• Infuse over 30 minutes unless otherwise indicated.
• Therapy should be continued for at least 2-3 days after symptoms
of infection have disappeared.
•
Assess
client with a history of hypersensitivity reaction. “for penicillin or cephalosporin.”
Assess
client financial status. These drugs are usually expensive.
• If GI upset occurs administer. Drugs with meals. “Should be
administered on empty stomach”.
• Obtain liver & renal studies.
