Ranitidine HCL
Trade names: Zantac , Randine
Class: ulcer healing drug "H2-receptor antagonists "
Pregnancy:
(Category B) Action:
It
competitively inhibits gastric acid secretion by blocking the effect of
histamine on histamine H2-receptors. Uses:
Short-term (up to 8 wks) &
maintenance treatment of duodenal ulcer & 
treatment of benign gastric ulcer .
treatment of benign gastric ulcer .
Management of hypersecretion of gastric acid .
Reflux esophagitis.
Dose:
by mouth, 150 mg twice daily or 300 mg at
night
Prophylaxis of NSAID-induced duodenal ulcer, 150 mg twice
daily
Reflux oesophagitis, 150 mg twice daily or 300
mg at night for up to 8 weeks, By intramuscular injection, 50 mg every 6–8
hours
By slow intravenous injection, 50 mg diluted
to 20 mL and given over at least 2 minutes; may be repeated every 6–8 hours
Prophylaxis of stress ulceration, initial slow
intravenous injection of 50 mg then
continuous infusion, 125–250 micrograms/kg per hour Contraindications:
Liver cirrhosis, impaired renal & hepatic function .
Side effects:
Constipation , nausea , vomiting,
diarrhea, headache Dizziness , malaise , vertigo , bradycardia or tachycardia
Pancytopnea , rashes, bronchospasm , alopecia.
Nursing
considerations:
§
Dilute for I.V. use ( 50 mg
in 20 ml of 0.9% Nacl) .
§
Note any evidence of renal
or liver disease.
§
Obtain baseline liver &
kidney function.
§
Note for signs of infection
.
Adequate hydration for problem of diarrhea.
