Penicillin G sodium
Trade names: Crystalline Penicillin
Class: Antibiotic " Broad-spectrum
penicillin ' Pregnancy:
(Category B)
Action:
Inhibit bacterial cell wall
synthesis
Uses:
Gram +Ve cocci “streptococci, meningococci,
pneumococei" 
Subacute bacterial endocarditis caused by
group A streptococci.
Gonorrhea due to gonococci.
Diphtheria, tetanus, anthrax, gas gangrene.
Prophylaxis for rheumatic fever.
Dose:
100 000 -300 000 unit/kg/day in divided doses 4-6 hours
Contraindications:
Hypersensitivity .
Side effects:
Rapid I.V. administration may cause
hyperkalemia & cardiac arrhythmias. Diarrhea , abdominal cramps \pain , nausea,
vomiting.
Psendomembranous colitis, thrombocytopenia,
leucopenia Thrombophlebitis + Electrolytes imbalance
following I.V. use. Hepatotoxicity.
Nursing
considerations:
I.M. is preferred, minimize discomfort by
using solution of up to 100,000 units \ml. Monitor intake & output (I & O) .
Solution may be stored at room temp. for 24 hr
or in refrigerator for 1 week.
Use 1% - 2% lidocaine as a diluent for I.M.
use to decrease pain at injection site. 
Note the penicillin G should not be mixed
during I.V. administration with the following drugs: aminophylline, gentamycin,
heparin, vancomycin & sodium bicarbonate.
