Glibenclamide ' Daonil '
Trade name:
daonil.
Pregnancy: (Category C)
Class: First generation sulfonylurea.
Indication:
Non- insulin dependent diabetes mellitus (NIDDM) (type II).
• Patients should be subjected to a 7 day therapeutic trial.
• Decrease in blood sugar, decrease in glucosuria &
disappearance of Polyuria, polydipsia, & polyphagia indicate that patient
can be managed on oral antidiabetic agents.
Contraindications:
§ Type I of D.M.
§ Renal & liver disease.
§ Diabetes complicated by recurrent episodes of ketoacidosis.
Dose:
Initially
½ -1 tablet (5mg) daily, increased by 2.5 – 5 mg weekly to achieve the desired
response. max. 15 mg daily. Side effects:
§ Hypoglycemia (most common).
§ Nausea, heartburn, diarrhea
§ Headache, dizziness, general weakness.
§ Pancytopnea.
§ Chronic use increases risk of cardiovascular mortality. § Cholestatic jaundice (rare).
Nursing
considerations:
§ Drugs may be taken with food to minimize GI upset.
§ Stop the medication if signs of side-effects or ketoacidosis
appear
§ Explain the importance of carrying candy or sugar at all times
to counteract hypoglycemia should it occur.
Provide
the client & family with a printed chart explaining symptoms of
hypoglycemia, hyperglycemia & instructions concerning what to do for each. § Explain the importance of exercise &
adhering to the prescribed diet.
