Aminophylline:
Class: Antiasthmatic,
bronchodilator
Pregnancy: (Category C)
Action: Relaxes smooth muscles of bronchi causing
bronchodilation and increasing vital capacity of the lungs Uses:
• Prophylaxis and treatment of bronchial asthma.
• Reversible bronchospasm associated with C.O.P.D.
Dose :
By mouth, 100–300 mg, 3–4
times daily, after food
slow intravenous injection:
over at least 20 minutes" not previously treated with
theophylline"
(with close monitoring) (5 mg/kg) Intravenous
infusion: 0.3 – 0.7 mg/kg/hour Contraindications:
• Hypersensitivity
Hypotension
• Coronary artery disease (angina pectoris).
Side effects:
• Nausea, vomiting, epigastric pain.
• Rectal irritation following use of suppositories.
• Headache, dizziness, Hypotension, arrhythmias ( tachycardia)
• Aminophylline given by rapid I.V. may produce hypotension,
flushing, precordial pain, Headache & dizziness.
Nursing
considerations:
• Dilute drugs & maintain proper infusion rate.
• Assess client for any history of hypersensitivity.
• Obtain baseline blood pressure and pulse prior to starting
therapy, monitor B.P. & pulse closely during therapy.
• Observe closely for signs of toxicity.
• To avoid epigastric pain (when administered orally) give the
medication with meals.
• Monitor for serum level of theophylline.
Instruct the client to increase intake of fluids to liquefy secretions
