Pancuronium
Trade names: Pavulon
Class:
Non-depolarizing muscle
relaxants
Pregnancy:
(Category C) Action:
Pancuronium, is a non-depolarizing
neuromuscular blocking agent that competes with acetylcholine for cholino-
ceptive sites at the postjunctional membrane and thereby blocks competitively
the transmitter action of acetylcholine resulting in muscle paralysis.
Uses:
Pancuronium
bromide is indicated as an adjunct to general anesthesia to facilitate tracheal
intubation and to provide skeletal muscle relaxation during surgery or
mechanical ventilation.
Dose:
by intravenous injection, initially for
intubation 50–100 micrograms/kg then 10– 20 micrograms/kg as required; CHILD
initially 60–100 micrograms/kg, then 10–
20 micrograms/kg, Neonate 30–40 mic/kg
initially then 10–20 micrograms/kg
Intensive care, by intravenous injection, 60 mic/kg every 60–90 minutes Contraindications:
Hypersensitivity.
Side effects: 
chest pain 
fever
chest pain fever
pain, redness, swelling or irritation at the
injection site
shortness of breath, wheezing unusual muscle weakness or tiredness 
flushing (reddening of skin)
rash, itching Nursing considerations:
May administered undiluted by rapid I.V
injection as requested.
Monitor parameters ( Heart rate, blood
pressure, assisted ventilation status, cardiac monitor, and ventilated
required.
Nurse should not alter the pt's state of
unconsciousness
