Cloxacillin
Trade name: Orbenin
Class: antibiotic
"penicillinase-resistant penicillins" Pregnancy: (Category B)
Action: Inhibit bacterial cell wall
synthesis.
Uses:
• Infections caused by penicillinase- producing staphylococci,
streptococci, pneumococci.
• Osteomylitis
• pneumonia
• infected wounds & burns
Septic arthritis.
Dose : by mouth, 250–500 mg every 6 hours,
at least 30 minutes before food; Child under 2 years
quarter adult dose; 2–10 years half adult dose
By
intramuscular injection, 250–500 mg every 6 hours; Child
under 2 years quarter adult dose; 2–10 years half adult dose
By slow intravenous injection or
by intravenous infusion, 0.25–2 g every 6 hours; Child
under
2 years
quarter adult dose; 2–10 years half adult dose
Endocarditis 12 g daily in 6 divided doses for 4
weeks Osteomyelitis up to 8 g daily in 3–4
divided doses Contraindications:
Hypersensitivity to penicillins & cephalosporin.
Side effects:
§ Allergic: skin rashes, pruritis, wheezing, fever…. .
§ Diarrhea, abdominal cramps pain, nausea, vomiting.
§ Psendomembranous colitis, thrombocytopenia, leucopenia § Thrombophlebitis + Electrolytes imbalance following I.V.
use. § Hepatotoxicity.
Nursing
considerations:
§ Administer on an empty stomach.
§ Refrigerate reconstituted solution & discard remaining
amount after 14 days.
§ N.B.: To prepare oral suspension,
add amount of water stated on label and shake well.
§ Shake the bottle well before each use.
